Thursday, January 31, 2013

NASA's Cassini watches Saturn storm choke on its own tail

Jan. 31, 2013 ? Call it a Saturnian version of the Ouroboros, the mythical serpent that bites its own tail. In a new paper that provides the most detail yet about the life and death of a monstrous thunder-and-lightning storm on Saturn, scientists from NASA's Cassini mission describe how the massive storm churned around the planet until it encountered its own tail and sputtered out. It is the first time scientists have observed a storm consume itself in this way anywhere in the solar system.

"This Saturn storm behaved like a terrestrial hurricane -- but with a twist unique to Saturn," said Andrew Ingersoll, a Cassini imaging team member based at the California Institute of Technology, Pasadena, who is a co-author on the new paper in the journal Icarus. "Even the giant storms at Jupiter don't consume themselves like this, which goes to show that nature can play many awe-inspiring variations on a theme and surprise us again and again."

Earth's hurricanes feed off the energy of warm water and leave a cold-water wake. This storm in Saturn's northern hemisphere also feasted off warm "air" in the gas giant's atmosphere. The storm, first detected on Dec. 5, 2010, and tracked by Cassini's radio and plasma wave subsystem and imaging cameras, erupted around 33 degrees north latitude. Shortly after the bright, turbulent head of the storm emerged and started moving west, it spawned a clockwise-spinning vortex that drifted much more slowly. Within months, the storm wrapped around the planet at that latitude, stretching about 190,000 miles (300,000 kilometers) in circumference, thundering and throwing lightning along the way.

Terrestrial storms have never run into their own wakes -- they encounter topographic features like mountains first and expend themselves. But Saturn has no land to stop its hurricanes. The bright, turbulent storm head was able to chomp all the way around the planet. It was only when the head of the storm ran into the vortex in June 2011 that the massive, convective storm faded away. Why the encounter would shut down the storm is still a mystery.

By Aug. 28, after 267 days, the Saturn storm stopped thundering for good. While Cassini's infrared detectors continue to track some lingering effects in higher layers of Saturn's atmosphere, the troposphere -- which is the weather-producing layer, lower in the atmosphere -- has been quiet at that latitude.

"This thunder-and-lightning storm on Saturn was a beast," said Kunio Sayanagi, the paper's lead author and a Cassini imaging team associate at Hampton University in Virginia. "The storm maintained its intensity for an unusually long time. The storm head itself thrashed for 201 days, and its updraft erupted with an intensity that would have sucked out the entire volume of Earth's atmosphere in 150 days. And it also created the largest vortex ever observed in the troposphere of Saturn, expanding up to 7,500 miles [12,000 kilometers] across."

The vortex grew to be as large as the giant storm known as Oval BA on Jupiter. But Oval BA and Jupiter's more famous storm -- the Great Red Spot -- are not thunder-and-lightning storms. Jupiter's storms also have a quiet center, unlike the violence at the center of Saturn's storms.

"Cassini's stay in the Saturn system has enabled us to marvel at the power of this storm," said Scott Edgington, Cassini's deputy project scientist at NASA's Jet Propulsion Laboratory in Pasadena, Calif. "We had front-row seats to a wonderful adventure movie and got to watch the whole plot from start to finish. These kinds of data help scientists compare weather patterns around our solar system and learn what sustains and extinguishes them."

This storm was the longest running of the massive storms that appear to break out in Saturn's northern hemisphere once every Saturn year (30 Earth years). The longest storm of any size ever detected on Saturn actually unfolded over 334 days in 2009 in an area known as "Storm Alley" in the southern hemisphere, but it was about 100 times smaller in area than the latest northern storm.

The Cassini-Huygens mission is a cooperative project of NASA, the European Space Agency and the Italian Space Agency. JPL manages the mission for NASA's Science Mission Directorate, Washington. The Cassini orbiter and its two onboard cameras were designed, developed and assembled at JPL. The imaging team consists of scientists from the U.S., England, France and Germany. The imaging operations center is based at the Space Science Institute in Boulder, Colo.

For more information, visit: http://www.nasa.gov/cassini and http://saturn.jpl.nasa.gov .

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/GcxJjn6Go80/130131145455.htm

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Wednesday, January 30, 2013

Japanese airlines had Dreamliner battery issues before recent incidents

TOKYO (Reuters) - Japan's two biggest airlines replaced below-par lithium-ion batteries on their Boeing Co 787 Dreamliners in the months before separate incidents led to the technologically advanced aircraft being grounded worldwide due to battery problems.

Comments from both All Nippon Airways, the new Boeing jetliner's biggest customer to date, and Japan Airlines Co Ltd point to reliability issues with the batteries long before a battery caught fire on a JAL 787 at Boston's airport and a second battery was badly charred and melted on an ANA domestic flight that was forced into an emergency landing.

ANA said it changed 10 batteries on its 787s last year, but did not inform accident investigators in the United States because the incidents, including five batteries that had unusually low charges, did not compromise the plane's safety, spokesman Ryosei Nomura said on Wednesday.

JAL also replaced batteries on the 787 "on a few occasions", said spokeswoman Sze Hunn Yap, declining to be more specific on when units were replaced or whether these were reported to authorities.

ANA did, however, inform Boeing of the faults that began in May, and returned the batteries to their manufacturer, GS Yuasa Corp. A spokesman for the battery maker declined to comment on Wednesday. Shares of the company fell 1.2 percent.

Boeing spokesman Marc Birtel said the airplane maker could not comment as the U.S. National Transportation Safety Board (NTSB) has indicated this is now part of their investigation.

LITTLE HEADWAY

The New York Times earlier quoted an NTSB spokeswoman as saying the agency would include these "numerous issues" with the 787 battery in its investigations.

Under aviation inspection rules, airlines are required to perform detailed battery inspections once every two years.

Officials are carrying out detailed tests on the batteries, chargers and monitoring units in Japan and the United States, but have so far made little headway in finding out what caused the battery failures.

Japan's transport ministry said the manufacturing process at the company which makes the 787 battery's monitoring unit did not appear to be linked to the problem on the ANA Dreamliner that made the emergency landing.

The NTSB said on Tuesday it was carrying out a microscopic investigation of the JAL 787 battery. Neither it nor the Japan Transport Safety Board has been able to say when they are likely to complete their work.

The global fleet of 50 Dreamliners - 17 of which are operated by ANA - remain grounded, increasing the likely financial impact to Boeing, which is still producing the aircraft but has stopped delivering them, and the airlines that fly the Dreamliner.

Boeing is due to report its latest quarterly earnings later on Wednesday, and ANA posts its earnings on Thursday. ANA shares rose 0.56 percent on Wednesday.

(Reporting by Tim Kelly, Dominic Lau, James Topham and Alwyn Scott; Editing by Ian Geoghegan)

Source: http://news.yahoo.com/japanese-airlines-had-dreamliner-battery-issues-recent-incidents-062501058--finance.html

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Mexico Vs. Denmark: Where To Watch Live Stream Online; Preview, Team News And Prediction

To some extent it is not quite accurate to call the clash with Denmark a warm up. With the friendly taking place outside of FIFA?s designated international dates, Jose Manuel de la Torre is unable to call upon his European-based players.

However, it would be an overstatement to call the clash meaningless. Mexico?s youth teams have enjoyed phenomenal success of late, highlighted by an Olympics gold medal last summer, and many of those players will be looking to make their mark against the Danes.

In total there are 10 members of the Olympic squad present in Phoenix. The trio of Hector Herrera, Diego Reyes and Jorge Enriquez will all be hopeful of playing a key role in Mexico?s path to Brazil in 2014.

Like, Mexico, Denmark will also have something of a B team on display at the University of Phoenix Stadium. Morten Olsen?s squad only features players from the Danish Superliga, which is currently in its off-season.

The squad incudes a blend of youth and experience. Those looking to establish themselves in the international arena include Nordsjaelland defender Jores Okore and Copenhagen forward Andres Cornelius. While, at the other end of the age scale, 34-year-old winger Dennis Rommedahl is still going strong for the Danes.

?

Mexico (probable)

G: Corona

D: Aguilar, Reyes, Rodriguez, Nilo

M: Aquino, Herrera, Salcido, Fabian

F: Peralta, De Nigris

?

Denmark (probable)

G: Jensen

D: Dalsgaard, Okore, Hoegh, Kadril

M: Sloth, Silberbauer, Lorentzen

F: Rommedahl, Cornelius, Jorgensen

?

Prediction: The match provides an intriguing contest between sets of players from a middling European league and a Mexican league looking to show that it warrants greater respect on the world stage.

Denmark already have a game under their belts, having beaten Canada 4-0 at the weekend and will provide strong competition for El Tri. But Mexico look to have the greater quality in the final third and cheered on by the support in Phoenix should grab the win.

Mexico 2-1 Denmark

Where to watch: The international friendly will kick-off at 10 p.m. ET. Coverage will be provided? by ESPN2, with a live stream available on ESPN3.?

Source: http://www.ibtimes.com/mexico-vs-denmark-where-watch-live-stream-online-preview-team-news-prediction-1050638

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Mom gets 15 years in autistic son's tub drowning (Providence Journal)

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Mormon-founded Marriott supports DOMA repeal. So does eBay, Reuters, Aetna. (Americablog)

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Tuesday, January 29, 2013

Parrots can be great pets, but make sure to read up first | Reporter ...

Dunwoody resident Marie Frank with one of her cockatiels

Dunwoody resident Marie Frank with one of her cockatiels

When you ring the doorbell at Marie Frank?s Dunwoody home, she barely cracks the door.

?Come in quickly,? she says, opening the door just enough for you to squeeze through.

Once inside, the reason for her caution is clear. Frank has three pet cockatiels that fly freely about her home.

Dixie perches on the handle of her oven, singing to his reflection in the stainless steel appliance. Lucky hops over to the table where Frank is sitting, curiously inspecting her coffee mug.

Frank said her birds are always entertaining her. But she said most people don?t know what they are getting into when they buy a parrot.

?These are the best pets,? Frank said. ?But if you don?t treat them well, they can be your worst nightmare.?

Frank is passionate about teaching people about responsible bird ownership.

A-Pets-2Frank said when she got her first gray and yellow cockatiel, Dixie, she assumed it would be happy living in its cage. ?I had a 5-year-old son who wanted a parrot,? Frank said. ?I think people think ? like I did ? that you can buy a big cage and look at him because he?s pretty.?

But she soon learned that her bird needed to spend time outside of his cage, flying and interacting with her family.

?Dixie is kind of the one who trained us on how he wanted to be treated,? Frank said. ?To treat them properly, you have to give them little or no cage time.?

Since getting her first cockatiel, Frank has rescued three more and has traveled to Arizona to volunteer with a bird rescue sanctuary.

She said there are many things people don?t know about parrots ? the family of exotic birds that includes macaws, cockatoos and Amazons.

If birds are bored or unhappy in their cage, they can be very loud and destructive, she said.

Some birds will even pick out their feathers and bite their skin with their beaks if they are confined to a cage.

?People need to know they are social creatures, they do need stimulation, they do need interaction,? Frank said.

Frank said many people give away their parrots, annoyed by the noise the birds make. There are only a few bird rescue groups around the country, and there often isn?t much space.

?The rescues are bursting at the seams. They?re so overcrowded,? Frank said.

One reason those rescues are so crowded: birds have incredibly long life spans.

Smaller parrots like cockatiels can live up to 25 years. But some larger birds, like macaws and African Grey Parrots, have a life span of up to 100 years.

Ron Johnson, owner of Feathered Friends Forever, cares for 1,400 birds at his rescue facility near Augusta.

He said birds come to the rescue from around the country for a variety of reasons. Some have owners who have died, or owners who have moved and can no longer keep them. Some people turn their birds in because they are simply tired of being bitten by the birds or hearing them chirp.

Johnson said the problem is that breeders continue to sell the birds for a large profit.

?Breeders and pet stores don?t care what people buy so long as they collect their money,? Johnson said.

Johnson said someone recently dropped off a bird that was only six months old.

?A breeder convinced this lady that this was a quiet, lovable bird,? Johnson said. ?She paid $900 for the bird, $300 for the cage, and had it 48 hours because she couldn?t stand the noise that it made.?

He said it?s important to keep in mind that parrots are wild animals. They still have natural instincts that can make them unfriendly.

?They?re in a sense ?domesticated? in that they will take food from your hand and they will talk to you,? Johnson said. ?When it?s breeding season, you have Dr. Jekyll.?

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Source: http://www.reporternewspapers.net/2013/01/28/parrots-can-be-great-pets-but-make-sure-to-read-up-first/

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As BlackBerry 10 debuts, RIM readies its first Super Bowl ad

For the first time ever, RIM, which has seen its standing in the smart-phone market erode, will buy TV advertising space during the Super Bowl.

By Matthew Shaer / January 28, 2013

Research In Motion CEO Thorsten Heins shows off the BlackBerry 10 OS during the Blackberry Jam Americas in San Jose, Calif., last September. BB10 debuts this week.

Reuters

Enlarge

On Wednesday, Canadian tech company Research in Motion will unveil its long-awaited new operating system, BlackBerry 10. BB10 is a big deal for RIM: If the OS is a success, it could help the struggling RIM revive its fortunes. If it's a failure, RIM will likely continue to lose market shares to the Apple iPhone and phones running Google's Android OS.?

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Which is why, for the first time ever, RIM will give one of its products a spot on one of the biggest stages on earth: Super Bowl XLVII. According to the Wall Street Journal, RIM is planning on running at least one spot during the championship game, which will take place on Sunday in New Orleans.?

"A Super Bowl commercial is a great opportunity to show the re-designed, re-engineered and re-invented?BlackBerry to tens of millions of consumers on the largest advertising stage of the year," RIM exec Frank Boulben said in a statement. No word yet on exactly what the ads will look like, although we're hoping for something on the level of last year's "Halftime in America" spot. "Halftime in the smartphone wars," perhaps.?

We can picture it now: Scrappy RIM, playing the doggedly-determined long-shot...?

So hey, can BB10 save RIM? Well, in a smart piece over at the Telegraph, Matt Warman argues that the question is a complicated one ? RIM has long thrived in the business world, among corporate clients that prized the security and accessibility of RIM devices. And yet increasingly, these same clients have shown a willingness to adopt devices such as the Apple iPhone and the Samsung Galaxy S III.?

Here's Warman:?

So RIM must rapidly become cool among its affluent core, which so quickly ran for the iPhone and now accepts Samsung enthusiastically too. And it must also quickly make even its premium devices affordable to a fickle younger user base. In that sense, the quality of the phone is at best equally important to the perception of the brand. At worst, BB10 is simply too little too late for BlackBerry thanks to a lethal combination of being consistently decent but not outstanding when it comes to cool factor, hardware, software and app availability.

We tend to agree. It's not inconceivable that RIM could mount some kind of comeback ? there are signs that even the mighty Apple is losing its cache ? but it would require a significant rejiggering of the BlackBerry brand. Not to mention a phone and OS that consumers view as must-have.?

For more tech news, follow us on?Twitter:?@CSMHorizonsBlog

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/4PrKboN3Yjo/As-BlackBerry-10-debuts-RIM-readies-its-first-Super-Bowl-ad

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Monday, January 28, 2013

Grief turns to anger after Brazil club fire; band in custody

SANTA MARIA, Brazil (Reuters) - Relatives of the 231 people who died in a Brazilian nightclub fire demanded answers on Monday as to how it could have killed so many people, while police questioned the club's owner and members of the band whose pyrotechnics show allegedly caused the tragedy.

Several coffins, many draped with flags of the victims' favorite soccer teams, lined a gymnasium that has become a makeshift morgue since the fire in the early hours on Sunday, one of the world's deadliest such incidents in a decade.

The death toll was revised down overnight from 233 to 231, as officials said some names had been counted twice.

Eighty-two people remained hospitalized in and around the southern city of Santa Maria. At least 30 of them were in serious condition.

As shell-shocked residents attended a marathon of funerals starting in the pre-dawn hours on Monday, the focus began to shift to what will likely be a barrage of police investigations, lawsuits and recriminations aimed at politicians and others.

"We can't trust in the ability of city hall, or the police, or anybody who permits a party with more a thousand people under these conditions," said Erica Weber, who was accompanying her daughter to a funeral for one of her classmates.

Most of the dead were suffocated by toxic fumes that rapidly filled the Kiss nightclub after the band set off a pyrotechnics display at about 2:30 a.m, witnesses said.

State prosecutor Valeska Agostini told Reuters one of the club's owners and members of the band had been taken into police custody to answer questions although no arrests or criminal charges are likely until after the investigation is completed.

The band's guitarist, Rodrigo Lemos Martins, 32, said he doubted the band was responsible for the blaze. "There were lots of wires (in the ceiling), maybe it was a short circuit," Folha de S.Paulo newspaper quoted him as saying.

The band's accordion player, Danilo Jaques, 30, was among those killed but the other five members survived.

It seems certain others will share the blame for Brazil's second-deadliest fire ever. The use of a flare inside the club was a clear breach of security regulations, fire officials said, and witnesses said bouncers initially tried to prevent people from fleeing from the one functioning exit because they believed they were trying to skip out on their bar tabs.

Clubs and restaurants in Brazil are generally subject to a web of overlapping safety regulations, but enforcement is uneven and owners sometimes pay bribes to continue operating.

The investigation of the Kiss fire could drag on for years. After a similar fire at an Argentine nightclub in 2004 killed 194 people, more than six years passed before a court found members of a band criminally responsible for starting the blaze and causing the deaths.

That tragedy also provoked a massive backlash against politicians and led to the removal of the mayor of Buenos Aires.

Valdeci Oliveira, a legislator in Brazil's Rio Grande do Sul state where the weekend tragedy took place, said on his Twitter feed that he and his colleagues would seek to ban pyrotechnics displays in closed spaces such as nightclubs.

"It won't bring anybody back but we're going to introduce the bill," Oliveira said.

(Additional reporting by Eduardo Sim?es in S?o Paulo; Editing by Todd Benson and Bill Trott)

Source: http://news.yahoo.com/grief-turns-anger-brazil-club-fire-band-custody-141430117.html

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Gravity-Controlled Pac-Man Is Now Available for iOS and Android?and It Looks Quite Fun

I thought Not Pacman—a version of Pac-Man that uses gravity to control the yellow hungry monster—was awesome and needed to be ported to iOS and Android ASAP. Gizmodo reader Pierre-Yves Gatouillat agreed with that opinion and he did just that. He sent this via email: More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/I0TXX0FhkHA/gravity+controlled-pac+man-is-now-available-for-ios-and-android++and-it-looks-like-fun

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Cazenovia College Art Gallery to Show Art Faculty Work ? Madison ...

Images include untitled digital image by Allyn Stewart and Caterpillar Neckpiece, wearable art by Heather Bivens.

StewartAllyn 2013 faculty showHeather Bivens Caterpillar Neckpiece(Cazenovia, NY ? Jan. 24, 2013)? The Cazenovia College Art Gallery in Reisman Hall will host the Faculty Biennial Exhibition, Jan. 31 ? Feb. 15, with an opening reception on Thursday, Jan. 31 from 4 to 5:30 p.m. The exhibition and reception are free and open to the public.

This exhibition features an eclectic mix of media -?both two and three dimensional works, including graphic design, cartoon, mixed media sculpture, painting, fiber, ceramics, drawing and so much more. Among the faculty members who will show their work are:

Heather Bivens, of Baldwinsville, N.Y.,?associate lecturer of studio art;
Jo Buffalo, of Syracuse, N.Y.,?professor of studio art;
Corky Goss, of Syracuse,?professor of studio art;
Scott Jensen, of Hobart, N.Y.,?assistant professor of visual communications;
Jen Pepper, of Manlius, N.Y.,?associate professor of studio art;
Jeremy Randall, of Tully, N.Y.,?visiting instructor of studio art;
Lori Wilson, of New Berlin, N.Y.,?associate lecturer of studio art;
Allyn Stewart, of Cazenovia,?associate professor of visual communications;
Anita Welych, of Syracuse,?professor of studio art; and
Kim Waale, of Manlius,?professor of studio art.
For more information and a complete list of artists, please visit?www.cazenovia.edu/art-gallery. For information about the gallery, contact Gallery Director Jen Pepper, by e-mail to jpepper@cazenovia.edu.

The Cazenovia College Art Gallery in Reisman Hall, 6 Sullivan St., is on the corner of Sullivan and Seminary streets in Cazenovia. Hours during the academic year are: Monday through Thursday, 1-4 p.m. and 7-9 p.m.; Friday, 1-4 p.m.; and Saturday and Sunday, 2-6 p.m. Summer hours vary. Shows and receptions are free and open to the public. The gallery is handicapped accessible.

Source: http://madisoncountycourier.com/?p=41430

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Sunday, January 27, 2013

Turkish PM criticizes pre-trial detentions of military officers

ANKARA (Reuters) - Turkish Prime Minister Tayyip Erdogan has criticized the lengthy pre-trial detention of hundreds of military officers, suggesting it was sapping army morale just as Ankara vows to keep up pressure on Kurdish militants.

During his 10 years in power, Erdogan, whose party has moderate Islamist roots, has brought to heel the once all-powerful armed forces, which see themselves as guardians of secularism and regularly intervened in politics and carried out coups in previous decades.

Hundreds of serving and retired officers, including 20 percent of military generals, have been jailed pending trial since 2005 on conspiracy charges and plotting to overthrow the government.

But as initial public support for the investigations dwindles, with critics and even sympathizers saying cases have spiraled out of control, Erdogan has distanced himself from the trials.

"There are now close to 400 retired and serving officers inside. The most serious are accused of forming organizations or belonging to one. If the provisions for these are certain, then finish the job," Erdogan said late on Friday.

"But if there isn't certainty, then the hundreds of officers should be treated accordingly. This disrupts the entire morale of the Turkish armed forces. How can these people then fight terror?" he said in an interview with Turkish television.

While Erdogan has received praise for bringing the military under civilian control, the years defendants are spending in prison without conviction has raised fears the trials are a political witch hunt aimed at silencing opposition.

The first large-scale convictions came last September after a 21-month trial when more than 300 officers were handed prison sentences for plotting to topple Erdogan's government almost a decade ago. Hundreds more are still in jail awaiting trial.

Around 100 journalists are also in prison, as well as thousands of activists, lawyers, politicians and others. Most are accused of plotting against the government or supporting outlawed Kurdish militants.

Parliament voted to abolish the special courts used in coup conspiracy cases last July after Erdogan criticized prosecutors for acting as if they were "a different power within the state".

But the end of the special courts, established by Erdogan's government in 2005, will not affect existing prosecutions of the hundreds of military officers already in jail.

MILITANTS

Erdogan's latest comments also come after one of the most violent summers in three decades, with security forces locked in almost daily battles with militants from the Kurdistan Workers Party (PKK) and at a time of heightened tension with Syria.

Turkey has been one of Syrian President Bashar al-Assad's fiercest critics and has seen violence from the war in its southern neighbor spill into its own territory. While Ankara does not want to get sucked further into the conflict, it has threatened cross-border military action if needed.

Turkey's conscript army is the second largest in NATO.

The PKK, designated a terrorist group by Ankara, the United States and the European Union, took up arms in 1984 and more than 40,000 people, mostly Kurds, have been killed since then.

The state-run Anatolian news agency reported on Saturday the military killed more than 1,500 "terrorists" inside and outside Turkey last year, citing the country's general staff. Turkish warplanes regularly launch air strikes on PKK targets in northern Iraq, where the guerrillas have bases.

Reuters could not independently verify the militant death tolls and Turkey's military rarely talks to the media.

Security forces, including army and police, have taken heavy casualties over the past year with PKK militants stepping up attacks on convoys and outposts.

Hopes of an end to the conflict grew, however, after the government acknowledged state intelligence officials were talking to jailed PKK leader Abdullah Ocalan.

While backing moves toward peace, Erdogan has vowed military operations will continue until the PKK disarms, a stance Kurdish politicians say undermines efforts to build trust.

(Writing by Jonathon Burch; Editing by Jason Webb)

Source: http://news.yahoo.com/turkish-pm-criticizes-pre-trial-detentions-military-officers-191645332.html

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New production of Rossini's Cinderella a delight

FILE - In this Jan. 22, 2013 file photo Margarita Gritskova in the role of Tisbe, Tara Erraught as Angelina, Alessandro Corbelli as Don Magnifico and Valentina Nafornita as Clorinde, from left, perform during a dress rehearsal for the opera "La Cenerentola" by Gioachino Rossini, at the state opera in Vienna, Austria. There is no pumpkin-turned-coach on the stage, no glass slipper, no fairy godmother, and the action takes place in an imaginary Italian duchy in the 1950s. But Gioachino Rossini's take on Cinderella remains utterly magical in the new version being put on by the Vienna State Opera with the premiere on Sunday Jan. 27, 2013. (AP Photo/dapd, Lilli Strauss,File)

FILE - In this Jan. 22, 2013 file photo Margarita Gritskova in the role of Tisbe, Tara Erraught as Angelina, Alessandro Corbelli as Don Magnifico and Valentina Nafornita as Clorinde, from left, perform during a dress rehearsal for the opera "La Cenerentola" by Gioachino Rossini, at the state opera in Vienna, Austria. There is no pumpkin-turned-coach on the stage, no glass slipper, no fairy godmother, and the action takes place in an imaginary Italian duchy in the 1950s. But Gioachino Rossini's take on Cinderella remains utterly magical in the new version being put on by the Vienna State Opera with the premiere on Sunday Jan. 27, 2013. (AP Photo/dapd, Lilli Strauss,File)

FILE - In this Jan. 22, 2013 file photo Tara Erraught in the role of Angelina performs during a dress rehearsal for the opera "La Cenerentola" by Gioachino Rossini, at the state opera in Vienna, Austria. There is no pumpkin-turned-coach on the stage, no glass slipper, no fairy godmother, and the action takes place in an imaginary Italian duchy in the 1950s. But Gioachino Rossini's take on Cinderella remains utterly magical in the new version being put on by the Vienna State Opera with the premiere on Sunday Jan. 27, 2013. (AP Photo/dapd, Lilli Strauss,File)

FILE - In this Jan. 22, 2013 file photo Tara Erraught in the role of Angelina and Dmitry Korchak as Don Ramiro, from left, perform during a dress rehearsal for the opera "La Cenerentola" by Gioachino Rossini, at the state opera in Vienna, Austria. There is no pumpkin-turned-coach on the stage, no glass slipper, no fairy godmother, and the action takes place in an imaginary Italian duchy in the 1950s. But Gioachino Rossini's take on Cinderella remains utterly magical in the new version being put on by the Vienna State Opera with the premiere on Sunday Jan. 27, 2013. (AP Photo/dapd, Lilli Strauss,file)

FILE - In this Jan. 22, 2013 file photo Tara Erraught in the role of Angelina and Dmitry Korchak as Don Ramiro perform during a dress rehearsal for the opera "La Cenerentola" by Gioachino Rossini, at the state opera in Vienna, Austria.There is no pumpkin-turned-coach on the stage, no glass slipper, no fairy godmother, and the action takes place in an imaginary Italian duchy in the 1950s. But Gioachino Rossini's take on Cinderella remains utterly magical in the new version being put on by the Vienna State Opera with the premiere on Sunday Jan. 27, 2013. (AP Photo/dapd, Lilli Strauss,File)

FILE - In this Jan. 22, 2013 file photo singers perform during a dress rehearsal for the opera "La Cenerentola" by Gioachino Rossini, at the state opera in Vienna, Austria. There is no pumpkin-turned-coach on the stage, no glass slipper, no fairy godmother, and the action takes place in an imaginary Italian duchy in the 1950s. But Gioachino Rossini's take on Cinderella remains utterly magical in the new version being put on by the Vienna State Opera with the premiere on Sunday Jan. 27, 2013. (AP Photo/dapd, Lilli Strauss)

(AP) ? There is no pumpkin-turned-coach on the stage, no glass slipper, no fairy godmother, and the action takes place in an imaginary Italian duchy in the 1950s. But Gioachino Rossini's take on Cinderella remains utterly magical in the new version being put on by the Vienna State Opera.

While all operas stand or fall on the quality of their singers, La Cenerentola presents a particular challenge, with solos replete with florid vocalization, full-out crescendos and sustained, flowing melodic lines.

But all soloists passed the test with full honors ? and then some ? in the production that premiered Saturday.

As Angelina ? Rossini's Cenerentola, or Cinderella ? mezzo Tara Erraught unleashed an array of coloratura fireworks in a role that affords opportunities for vocal pyrotechnics like few others.

"Non piu mesta" ? where Angelina, the prince by her side, announces that she forgives her cruel step-sisters and step-father ? is considered one of opera's most difficult arias. No problem for Erraught. Her rendition perfectly mirrored Angelina's transition from a servant singing a simple ditty at the fireside to a princess in full embellished voice.

While he was describing the opera in general terms two centuries ago, feared Vienna critic Eduard Hanslick could have been referring to Erraught's performance when he wrote: "This ... Cinderella is in fact a Cinderella in clothing only; her singing brims over with pearls, velvet and silk."

A hard act to match ? and as Don Ramiro, Angelina's prince, Dmitry Korchak was almost equal to the task.

"Almost," only because his light tenor initially threatened to get lost in the orchestra. But Korchak gained in confidence ? and his voice in power ? effortlessly pinpointing his high C's in "Si ritrovarla io giuro," as he declared that he will find the girl who so enchanted him at the ball, no matter what it takes.

But to do so, he must get past Angelina's step-father, who keeps her in ashes while he plots the prince's marriage to one of his two daughters. As the bumbling Don Magnifico, Alessandro Corbelli was indeed Mr. Magnificent Saturday, bringing the mean and scheming persona to life in a humorously endearing way.

Apropos of mean and scheming: Valentina Nafornita and Margarita Gritskova are beauties visually and vocally but convincingly rotten to the core in their roles as Clorinda and Tisbe, Don Magnificio's preening daughters

Also good ? Vito Priante as Dandini, the prince's servant, and Ildebrando D'Arcengelo as Alidoro, the prince's philosopher. As this Cinderella's de-facto fairy godfather, he pulls the strings behind the scenes to bring the story to a happy ending.

But there is no happy ending in any opera unless the orchestra is up to scratch. With Rossini specialist Jesus Lopez-Cobos conducting, musicians of the Vienna State Opera delivered a sparking rendition of a vibrant and complex score. Good singing by members of the Vienna State Orchestra Choir rounded out the evening, in a production as pleasing visually as it was musically.

After the first performance flopped in 1817, Rossini was optimistic proclaiming: "People will love this opera."

They did Saturday.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-01-27-EU-Austria-Opera-La-Cenerentola/id-fec9702c839b48d6b50c8e54221e2894

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Italy central bank approves Monte Paschi bailout request

ROME/MILAN (Reuters) - Italy's central bank on Saturday gave its approval to a request by scandal hit bank Monte dei Paschi di Siena for 3.9 billion euros ($5.3 billion) of state loans, the latest step in the battle to revive the ailing bank.

The Bank of Italy's backing was the final stage required to free up the financial help for Italy's third biggest lender, which this week revealed loss-making derivatives trades that could cost it about 720 million euros.

After a meeting that lasted most of Saturday, the central bank issued a brief statement to say its board had given "a favorable opinion" on the bailout. It gave no further details.

The scandal surrounding Italy's oldest bank has hit its share price and prompted questions about how the risky deals could have been hidden from regulators.

The issue has shot to the center of the campaign for a February 24-25 national election and politicians have blamed the Bank of Italy (BOI), led by current European Central Bank President Mario Draghi at the time of the deals, for failing to spot them.

At Saturday's meeting the BOI's four member board, chaired by Governor Ignazio Visco, had to judge whether the bank's current and future capital adequacy and stability were sufficient to receive the loans.

The Tuscan bank was forced to seek state aid last year for the second time since 2009 after becoming one of just four European lenders that failed to meet tougher capital requirements set by regulators.

Under the loan scheme the bank will issue 3.9 billion euros of bonds to the Italian Treasury, with just under half of these replacing 1.9 billion euros of existing state help.

The lender's new management, appointed last year to turn it around, said on Friday the situation was "completely under control".

The bank will pay a hefty 9 percent coupon on the bonds, which are worth more than its current market capitalization of 3 billion euros. The coupon will increase by 0.5 percentage point every two years up to a maximum of 15 percent.

At a stormy meeting at Monte Paschi's Siena headquarters on Friday, shareholders approved two capital increases for 6.5 billion euros to be carried out if needed in the next five years, which are a condition of the state bailout.

That raises the prospect of possible nationalization, because if the bank cannot repay the state bonds or the coupons attached to them, it will have to issue shares to the Treasury.

Prime Minister Mario Monti said late on Friday he considered nationalization a "remote hypothesis".

TAXPAYERS' MONEY

Monti, bidding for a second term in the election, defended his government's decision to rescue it with taxpayers' money. "It's a loan, with a high interest rate," he said.

At the World Economic Forum in Davos on Friday Visco sought to deflect accusations the BOI had not done its job properly.

"It is wrong to insinuate that there was a lack of supervision by the Bank of Italy," he said, adding the BOI would cooperate with prosecutors investigating the lender.

Draghi, also in Davos, took no questions from reporters.

Visco's task was made more difficult by a report in the Corriere della Sera daily which included excerpts of a document drafted by six BOI inspectors expressing concerns over the two main trades under scrutiny as long ago as 2010.

That document would have been sent to the BOI's head of bank supervision at the time, Anna Maria Tarantola, who has since left the bank to become president of state broadcaster RAI.

Visco sidestepped questions about whether Draghi knew about the 2008-09 derivatives trades, which involved Japanese bank Nomura and Deutsche Bank.

Internal auditors at Monte Paschi had detected anomalies at the bank's finance department responsible for derivative trades three years ago, daily Il Sole 24 Ore said on Saturday.

Monte Paschi was already under investigation over its 9-billion-euro cash acquisition of smaller lender Antonveneta from Spain's Santander in 2007.

Santander had bought Antonveneta for 6.6 billion euros in a three-way break-up bid for Dutch bank ABN AMRO, and almost immediately sold it on to Monte dei Paschi netting a hefty gain.

(Additional reporting by Danilo Masoni; Editing by Andrew Heavens and Jason Neely)

Source: http://news.yahoo.com/bank-italy-board-meets-assess-monte-paschi-crisis-120432200--finance.html

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Saturday, January 26, 2013

Singer Tina Turner on path to Swiss citizenship

(Reuters) - Soul music legend Tina Turner has taken the first steps toward giving up her U.S. passport and becoming a citizen of Switzerland, the country she has called home for nearly 20 years.

The Zurich suburb of Kusnacht has approved Swiss citizenship for the "Proud Mary" singer, pending confirmation from other authorities in the country, a spokeswoman for Turner said on Friday.

Turner, who was born in Tennessee, moved to Switzerland in 1995 to join her German-born record producer partner Erwin Bach and has lived there since. She enjoys the privacy she receives there and has no plans to live elsewhere, the spokeswoman said.

"I'm very happy in Switzerland and I feel at home here," Turner, 73, was quoted as telling the Swiss daily newspaper Blick.

The eight-time Grammy winner retired from performing after her last tour, which ended 2009. Her hits with Ike Turner and as a solo artist include "What's Love Got To Do With It," "Private Dancer" and "River Deep - Mountain High."

(Reporting by Lisa Richwine, editing by Jill Serjeant and Xavier Briand)

Source: http://news.yahoo.com/singer-tina-turner-path-swiss-citizenship-211434319.html

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Boating Safety Class enrollment opens | Batavia Sports ...

13 Secrets the Weight Loss Pros Don't Tell You

?Good Morning America? teamed up with Reader?s Digest on a special series, ?13 Things Experts Won?t Tell You.?

This month, Reader?s Digest unveils the secrets weight loss professionals won?t tell you, like how to maximize your workouts, what may be holding you back from losing weight and how to get the most bang for your buck.

1. Do not arrive at a training session in the following states: a. on an empty stomach, b. coming off a cold/stomach bug, or c. on four hours? sleep. It wastes your time and a personal trainer?s when your body isn?t fueled, hydrated and ready to work.

2. If you find your workouts are getting a little stale, a trainer is a great way to put some pep in your push-ups. If you can?t afford one, get some friends together for a small group session. They cost less per person ? and working out with friends is proven to improve your commitment and overall weight loss.

3. To kick start your metabolism, opt for intervals. In a recent study, women who did 20 minutes of cycling sprints lost three times as much fat as those who cycled slowly and steadily for 40 minutes.

4. When you hit the point where you think you can?t go on, imagine you have a trainer right next to you, cheering for you. Studies show that actively encouraging yourself improves outcomes.

5. You can do OK at the drive thru. There are now some reasonable options if you look for them.? Stay away from anything with the word ?crispy,? steer clear of all mayo-heavy sauces (use mustard instead) and stick to no-fat dressing.

6. Nibble on the move. If you are shopping and fading from hunger, avoid settling in at the food court and, instead, nibble your way through a shopping marathon.? Pick up a snack, such as a hot pretzel, a small bag of roasted nuts from a kiosk or even a chicken taco and nibble on the move.? Portable meals can still weigh you down, so check calorie counts?on your mobile phone before you go.

7. Douse your afternoon slump or hunger pangs with water.? The energy drop that hits in afternoon is likely a combination of perfectly natural factors ? the results of a light lunch, mild dehydration, a momentarily lack of iron or a crash off that coffee you had at the late-morning meeting.? Before wandering to the cafeteria or fridge, start your recovery with a tall glass of water, which boosts your blood flow and, as a side benefit, makes you feel full.

8. It?s hard to win against a cookie. While food is not addictive the way cocaine or alcohol is, there are some uncanny similarities.? When subjects at Monell Chemical Senses Center in Philadelphia were shown the names of foods they liked, the parts of the brain that got excited were the same parts activated in drug addicts.

9. Your bedroom, not the kitchen might be making you fat. Sleep deprivation upsets our hormone balance, triggering both a decrease in the hormone leptin (which helps you feel full) and an increase of the hormone ghrelin (which triggers hunger).? As a result, we think we?re hungry even though we aren?t ? and so we eat.? Sleep may be the cheapest and easiest obesity treatment there is.

10. Your weight really is genetic. When scientists first discovered a gene in certain chubby mice, they called it simply the fatso gene.? Turns out, people with two copies of the gene were 40 percent more likely to have diabetes and 60 percent more likely to be obese than those without it.? Those with only one copy of the gene weighed more too.? But your ?destiny? is no excuse.

11. Ear infections can taint your taste buds. In one study of more than 6,000 people, researchers found that people over age 35 who had suffered several ear infections had almost double the chance of being obese.? Why?? These infections can damage a taste nerve running through the middle ear.? When researchers found the at former ear-infection patients were a little more likely to love sweets and fatty foods, they theorized that the damaged nerve might cause them to have a higher threshold for sensing sweetness and fattiness.

12. Fat might be your mom?s fault. A growing body of science suggests that sugary and fatty foods consumed even before you?re born can mess with your weight.

13. At dinner, make yourself useful serving people and cleaning up.? It gets you away from your plate, but still makes you a vital part of the meal.

*Web Extra Tips: What Your Personal Trainer Won?t Tell You*

  • If you concentrate on the exercise you are doing with the same intensity as talking about the latest gossip about your life, you would find it easier.
  • Trainers know you are eating more than you tell them.
  • It takes more than writing a check or showing up for training sessions to make you fit and healthy. It?s what you do before and after you meet with your trainer, including choices with food, alcohol and workouts, and a commitment to a new lifestyle.
  • Ask you trainer what she or he does to keep educated in the field. An educated trainer will get better results and provide variety to keep you engaged and motivated in your workouts.
  • When you are late, it is a waste of your money, a waste of my time and disrespectful.
  • Trainers see through your stall tactics. ?I think I need to fill my water bottle.? ?Let me get a dry towel real quick.? ?Oh, I need to go to the bathroom again.? Nice try. But you?re paying for the session, so make every minute count.
  • There is a difference between pain and burn, and you need to be honest with your trainer about which you?re feeling. If you push so hard that you injure yourself, you both lose.
  • Whatever the text or email says, it can wait until you?re done with your workout. And no, you cannot text and put forth 100 percent effort at the same time.
  • The trainer does not have time to get sick. Cancel your session if you?re carrying germs.
  • Gear matters. Don?t expect to get maximum performance and results by working out in the ratty gym shoes and shorts you dug out of that old box of college dorm clothes. Invest in a good pair of sneakers. Your feet and joints will thank you, and so will your trainer.
  • Remember that a 30-minute session at max effort is better ? and cheaper ? than 60 minutes of dawdling and half-effort.
  • Stop whining and push through those last few reps.

Source: http://abcnews.go.com/blogs/health/2013/01/25/13-secrets-the-weight-loss-pros-dont-tell-you/

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Friday, January 25, 2013

When Was the Last Time You Wrote Your Spouse a Love Letter ...

Photo Credit: Jessica Diamond via Flickr

I am really feeling this new issue of Ebony Magazine. Anything celebrating love and relationships immediately captures my attention; and the three different covers highlighting celebrity couples is no exception. As I read the articles on the couples featured, I was inspired and felt somewhat school girl like as I thought about the start of my own relationship. What I enjoyed the most?were the love letters each husband wrote to their wife. I remember early on in my relationship with my husband,?he was in Atlanta and I was in Chicago. Although we were only dating at that point I knew we had something special and he would be my husband.

Our long distance relationship wasn?t always easy. During that time apart we had phone conversations and visits back and forth, but what I think was most exciting were the weekly?love letters we sent. Yes, we?wrote letters all the time. Even though we may have had the same conversations over the phone, there was something special about writing to him. The letters allowed me to express myself even further than I had been able to do over the phone. I remember the days of?racing to the mailbox?to check for his letters. Our letters were exciting and?filled with love.

Those letters kept us engaged and anxious to spend time together. They also maintained our focus when we were apart. Our relationship, at that time, required us to try even harder. I believe it created a great foundation, one that we still benefit from today. We did get married, settled down, and started our life together. Life took over, children arrived, careers took off ?and the love letters stopped. Now, we don?t actually need the love letters to know or feel the love in our marriage, because our actions show it. However, the Ebony article helped me to realize how much I miss them. It might not make a whole lot of sense to write a love letter to someone you communicate with and see everyday, but I desire to bring them back into our relationship. This year we will celebrate 15 years of marriage and while it gets better with each year, I want to make sure we don?t forget to incorporate those small displays of affection that brought us so much joy in the beginning.

Even as I began writing this article I pulled out those letters I mentioned above. I have held on to each one of them. Ahh the memories. Just reading them reminded me of the excitement and passion that was so evident during our dating relationship. Love feels good when it?s done right. Expressing love to our spouse can come in various forms, the most import thing is that we take every opportunity to show it. It?s the little things that count.

BMWK?? When was the last time you wrote your spouse a love letter?


About the author

Tiya Cunningham-Sumter is a Certified Life & Relationship Coach and founder of Life Editing. She helps couples and individuals rewrite their life to reflect their dreams. Tiya was featured in Ebony Magazine in the October 2008 and November 2010 issues. She resides in Chicago with her husband and two children.


Source: http://blackandmarriedwithkids.com/2013/01/when-was-the-last-time-you-wrote-your-spouse-a-love-letter/

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Wolfram Alpha's new Facebook tool feeds your self-obsession

11 hrs.

As uncomfortable as it can be to admit, odds are that you occasionally really enjoy poring over information about ... yourself. It's OK, most of us secretly obsess over social media analytics and statistics ??and tools like?one offered by Wolfram Alpha don't exactly discourage those moments of narcissism.

Wolfram Alpha's Personal Analytics Tool for Facebook has been around for a while, but it received a significant update on Wednesday. "There?s much more to analyze, see, and do,"?John Burnham, a research and development fellow at Wolfram Alpha, explained on the answer engine's official blog.

To take a peek at your own analytics, you need to grant Wolfram Alpha access to your Facebook account and fork over your email address along with a couple of other details. Once you've done that, you'll have a few moments to twiddle your thumbs as Wolfram Alpha parses your Facebook. And then you'll be overloaded with so much information about things you never even wondered about before.

How are all your friends connected? Do certain individuals have a lot of friends in common with you ("social insiders")? Does someone have almost no friends in common with you (a "social outsider")??How would it look if all your friends were color-coded by relationship status, age, sex, and so on? Who comments on your posts the most? Are all your hometown friends married? Who is your most popular college friend?

Take a deep breath! There are far more questions to explore.

Who is your most distant friend, geographically speaking? Which of your friends lives nearest to the equator? When do you post photos most frequently? Which English words do you use the most in posts? Who is your oldest friend?

The stream of details provided by Wolfram Alpha's?analytics tool is?seemingly endless and, thanks to the way Wolfram Alpha structures data, you can click around and explore things from plenty of angles, zooming in on whichever specifics draw you in the most. If you like what you see,?you can even give the answer engine permission to periodically collect information "to be able to show you an evolution of your Facebook profile over time."

Silliness aside, Wolfram Alpha's tool can be quite revealing. Using it, I discovered that I'm significantly more prone to posting links in the early afternoon and photos in the evenings (likely because I tend to share stories I've written while at work).?I also learned that I have a habit of using the words "folks," "man," "now," "love," and "actually" far more than I realized.

Man, folks! I actually love how much I now know about myself thanks to this tool.

Want more tech news?or interesting?links? You'll get plenty of both if you keep up with Rosa Golijan, the writer of this post, by following her on?Twitter, subscribing to her?Facebook?posts,?or circling her?on?Google+.

Source: http://www.nbcnews.com/technology/technolog/wolfram-alphas-new-facebook-analysis-tool-feeds-your-self-obsession-1C8091334

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Love triumphs over hate to make exotic new compound: Compound could be useful in batteries, semiconductors, memory devices

Jan. 24, 2013 ? Northwestern University graduate student Jonathan Barnes had a hunch for creating an exotic new chemical compound, and his idea that the force of love is stronger than hate proved correct. He and his colleagues are the first to permanently interlock two identical tetracationic rings that normally are repelled by each other. Many experts had said it couldn't be done.

On the surface, the rings hate each other because each carries four positive charges (making them tetracationic). But Barnes discovered by introducing radicals (unpaired electrons) onto the scene, the researchers could create a love-hate relationship in which love triumphs.

Unpaired electrons want to pair up and be stable, and it turns out the attraction of one ring's single electrons to the other ring's single electrons is stronger than the repelling forces.

The process links the rings not by a chemical bond but by a mechanical bond, which, once in place, cannot easily be torn asunder.

The study detailing this new class of stable organic radicals will be published Jan. 25 by the journal Science.

"It's not that people have tried and failed to put these two rings together -- they just didn't think it was possible," said Sir Fraser Stoddart, a senior author of the paper. "Now this molecule has been made. I cannot overemphasize Jonathan's achievement -- it is really outside the box. Now we are excited to see where this new chemistry leads us."

Sir Fraser is the Board of Trustees Professor of Chemistry in the Weinberg College of Arts and Sciences at Northwestern. In the late 1980s, he was one of the early pioneers to introduce an additional type of bond, the mechanical bond, into chemical compounds.

The new Northwestern compound has attractive electronic characteristics and can be made quickly and inexpensively. Down the road, it may be possible to expand this first linked pair into a longer chain-like polymer where this methodology could be useful in new technologies for batteries, semiconductors and electronic memory devices.

Driven by curiosity, Barnes only began to look at the radical chemistry of the ring cyclobis (paraquat-p-phenylene) two years ago, nearly 25 years after the ring was first made.

"I wondered what would happen if we took it all the way to the max," said Barnes, the paper's first author and a member of Stoddart's group. "Can we take two of these rings, each with four positive charges, and make them live together?"

The rings repel each other like the positive poles of two magnets. Barnes saw an opportunity where he thought he could tweak the chemistry by using radicals to overcome the hate between the two rings.

"We made these rings communicate and love each other under certain conditions, and once they were mechanically interlocked, the bond could not be broken," Barnes said.

Barnes' first strategy -- adding electrons to temporarily reduce the charge and bring the two rings together -- worked the first time he tried it. He, Stoddart and their colleagues started with a full ring and a half ring that they then closed up around the first ring (using some simple chemistry), creating the mechanical bond.

When the compound is oxidized and electrons lost, the strong positive forces come roaring back -- "It's hate on all the time," Barnes said -- but then it is too late for the rings to be parted. "That's the beauty of this system," he added.

Most organic radicals possess short lifetimes, but this unusual radical compound is stable in air and water. The compound tucks the electrons away inside the structure so they can't react with anything in the environment. The tight mechanical bond endures despite the unfavorable electrostatic interactions.

The two interlocked rings house an immense amount of charge in a mere cubic nanometer of space. The compound, a homo[2]catenane, can adopt one of six oxidation states and can accept up to eight electrons in total.

"Anything that accepts this many electrons has possibilities for batteries," Barnes said.

"Applications beckon," Stoddart agreed. "Now we need to spend more time with materials scientists and people who make devices to see how this amazing compound can be used."

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Story Source:

The above story is reprinted from materials provided by Northwestern University, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. J. C. Barnes, A. C. Fahrenbach, D. Cao, S. M. Dyar, M. Frasconi, M. A. Giesener, D. Benitez, E. Tkatchouk, O. Chernyashevskyy, W. H. Shin, H. Li, S. Sampath, C. L. Stern, A. A. Sarjeant, K. J. Hartlieb, Z. Liu, R. Carmieli, Y. Y. Botros, J. W. Choi, A. M. Z. Slawin, J. B. Ketterson, M. R. Wasielewski, W. A. Goddard, J. F. Stoddart. A Radically Configurable Six-State Compound. Science, 2013; 339 (6118): 429 DOI: 10.1126/science.1228429

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/technology/~3/XJ_pqCmMTeI/130124150756.htm

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Thursday, January 24, 2013

Promising prognostic marker for aggressive breast cancer

Jan. 23, 2013 ? A team of researchers led by Goutham Narla, MD, PhD, at Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, and collaborators at the Mount Sinai School of Medicine and Erasmus Medical Center, have discovered a gene variant that drives the spread of breast cancer. Published in Science Translational Medicine, the study lays the early foundation for predicting which breast cancer patients may develop more aggressive disease and for designing more effective treatments.

"Breast cancer is a genetically complex disease and it remains a challenge to predict disease outcomes and which patients may benefit from more aggressive treatment," says Dr. Narla, assistant professor at Case Western Reserve University School of Medicine and medical geneticist at UH Case Medical Center Seidman Cancer Center. "Our research has uncovered a promising gene marker that will not only help us better identify tumors that behave badly but provide a basis for developing and 'personalizing' therapies to better treat our patients."

The research team discovered that a mutant gene, KLF6-SV1, was linked to the recurrence and metastasis in women with breast cancer. The incorrect splicing of the KLF6 gene essentially creates a protein that causes cancer cells to spread or metastasize. The researchers examined the tumors of 671 breast cancer patients in a tumor bank at Erasmus University Medical Center (Rotterdam, The Netherlands) and found that those whose tumors expressed high levels of the gene variant were 50 percent more likely to die. Since recurrence and metastasis are the major causes of death in breast cancer, this finding will provide a new direction of research to both identify women at risk and to develop targeted drugs that block the process of metastasis.

"This study presents biological proof that this splice variant can potentially be a marker for determining which early stage breast cancer patients will have disease progression," adds Dr. Narla. "More studies need to be done, but this could provide an important prognostic marker to determine which patients need to be treated more aggressively or watched more closely."

Dr. Narla came to UH Case Medical Center and Case Western Reserve in spring, 2012, from Mt. Sinai and is the first Harrington Distinguished Scholar (Early Career Award). This inaugural award provides physician-scientists with the ability to tap into grant funding and a peer network of innovators and mentors within the infrastructure of the Harrington Discovery Institute at UH Case Medical Center. The Institute is part of the $250 million Harrington Project for Discovery & Development, which was launched in February, 2012, with a $50 million gift to UH from the Harrington family of Hudson, OH.

Dr. Narla's laboratory focuses on the identification and characterization of the genes and pathways involved in cancer metastasis. By studying the functional role of the KLF6 tumor suppressor gene, Dr. Narla and his team have identified new signaling pathways regulated by this gene family thus providing new insight into cancer diagnosis and treatment. The team's research found that KLF6 and FOXO1, both tumor suppressor genes, are turned off as cancer spreads through the body. Since first discovering the KLF6 gene 13 years ago as a medical student at Mount Sinai School of Medicine in the laboratory of Dr. Scott Friedman, Dr. Narla has been involved in the identification and characterization of the gene and its role in cancer development.

"In this new research as well as previous studies, Goutham and his team have uncovered important and previously unrecognized genetic markers in cancer," said Stanton Gerson, MD, Director of the Case Comprehensive Cancer Center and the UH Case Medical Center Seidman Cancer Center. "This work highlights how understanding the basic mechanisms regulating cancer development and progression can lead to significant advances in the treatment of cancer. We are so pleased to have a physician-scientist of his caliber at our cancer center and are excited about the impact of this important work."

Dr. Narla will work with the breast cancer team, led by Lyndsay Harris, MD, to study further KLF6-SV1's potential as a prognostic marker for patients with poor outcomes. The group also will work to develop novel therapeutics that can turn the protein off and cause the cells to become less aggressive.

"We look forward to continuing this work to further define the role of KLF6-SV1 on the molecular basis of tumor progression and metastasis in breast cancer," says Dr. Harris, Director of the Breast Cancer Program at UH Case Medical Center and Professor, Medicine-Hematology/Oncology at the School of Medicine. "These findings provide us with a biomarker of more aggressive disease and a target for new therapies. This will potentially enable us to develop more "personalized" treatments for patients and thereby reduce breast cancer mortality."

This work was supported by the Howard Hughes Medical Institute (HHMI). Additional support for Dr. Narla's research comes from the Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Case Western Reserve University Institute for Transformative Molecular Medicine, and the Mount Sinai School of Medicine. Dr. Narla is also supported by an early physician scientist career award from the HHMI.

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The above story is reprinted from materials provided by Case Western Reserve University, via Newswise.

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Journal Reference:

  1. R. Hatami, A. M. Sieuwerts, S. Izadmehr, Z. Yao, R. F. Qiao, L. Papa, M. P. Look, M. Smid, J. Ohlssen, A. C. Levine, D. Germain, D. Burstein, A. Kirschenbaum, A. DiFeo, J. A. Foekens, G. Narla. KLF6-SV1 Drives Breast Cancer Metastasis and Is Associated with Poor Survival. Science Translational Medicine, 2013; 5 (169): 169ra12 DOI: 10.1126/scitranslmed.3004688

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/ZtMG3j-FSZI/130123195106.htm

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