Expression and Clinical Significance of Fatty Acid Synthase in ...

[Abstract]

BackgroundOvarian cancer is the most common of the three female genital cancer, and its incidence rate is second only to cervical cancer and uterine cancer. The mortality rate is relatively high. So far, according to domestic and foreign clinical data statistics, the five-year survival rate is only 25% -30%. The malignant behavior of tumor tissue is closely related to its specific material metabolism and energy metabolism. Fatty acid has an important role in cell metabolism, structure and function. Fatty acid synthase (FASN) is a key endogenous fatty acid synthesis enzyme, so in recent years studies on the expression of FASN in malignant tumors become one of the hotspot. In order to identify the early and effective diagnosis indicators of ovarian cancer, we study the expression of FASN in ovarian cancer and its clinical significance.ObjectiveTo study the expression of FASN in the normal ovarian tissue, benign ovarian tumors, borderline tumors, ovarian carcinoma, and its correlation with ovarian cancer, further to look for early diagnosis biological indicators.MethodsThe expressions of FASN in 13 normal ovarian tissues,13 benign ovarian tumors,13 cases of borderline tumors and 56 cases of ovarian cancer tissues were studied by Immunohistochemical method.Results1. FASN was not expressed in normal ovarian tissue, but largely expressed in benign ovarian tumors, borderline tumors and malignant tumors, and the positive expression rates were 15.4%,30.8%,67.1% respectively, showing a gradual upward trend.2. Compared with normal group, the expression of FASN in either malignant group or the junction group has a significant difference, and compared with either the benign group or the junction group, its expression in the malignant group was significant difference (P<0.05); while the comparison of the normal group with the benign group or the benign group compared with the junction group was not significant difference (P> 0.05).3. The expression level of FASN is not related to age, degree of differentiation, lymph node metastasis or ascites cytology, but highly related to the cancer clinical stages (P<0.05).4. The survival correlation analysis of ovarian cancer patients showed that compared to the negative expression group, the 3-year survival rate was significantly lower in the positive expression group (P<0.05).Conclusion1. The expression level of FASN in normal ovarian tissue, benign, borderline and malignant tumors showed gradual upward trend, suggesting that the occurrence of ovarian cancer, development and invasion may be related to the expression level of FASN.2. In ovarian cancer, the expression level of FASN may be not related to patient age, tumor differentiation, lymph node metastasis and ascites cytology, but highly related to the clinical stages of the tumor.3. FASN can be used as an indicator of early diagnosis of ovarian cancer, one of which is to provide early diagnosis of ovarian cancer, a new basis, and the degree of malignancy of ovarian cancer in clinical analysis and monitoring of certain prognostic guide.

Title: Expression and Clinical Significance of Fatty Acid Synthase in Ovarian Cancer

Category: Tumor Biol

Filename: Expression and Clinical Significance of Fatty Acid Synthase in Ovarian Cancer.pdf

Pages: 195

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